Nomifensine maleate
(Merital, Hoechst-Roussel)

Fields ED
Department of Pharmacology,
Georgetown University
School of Medicine,
Washington, DC 20007-2195, USA.
Drug Intell Clin Pharm 1982 Jul-Aug; 16(7-8):547-52


Nomifensine is an isoquinoline antidepressant that inhibits the reuptake of dopamine at central synapses. It also inhibits norepinephrine reuptake but is only a weak inhibitor of 5-hydroxytryptamine. Open and controlled trials comparing nomifensine with placebo and other standard antidepressants have shown it to be an effective antidepressant in divided doses up to 200 mg/d. The full dosage range of 50-200 mg/d is well tolerated, and doses can be selected to suit patient disease, age, and therapeutic response. Minimal anticholinergic and sedative side effects and no impairment of psychomotor performance make nomifensine a suitable drug for use in a wide variety of ambulatory outpatients, including the elderly. A relative lack of cardiotoxicity and epileptogenic activity add to this profile; the safety of the drug, when taken in overdose, has been documented. However, the place of nomifensine in the treatment of depression, relative to other antidepressants, is still unclear.
Nomifensine: overview
Nomifensine: pharmacology
Noradrenaline and dopamine
Nomifensine: pharmacokinetics
Nomifensine and hemolytic anaemia
Nomifensine, noradrenaline and dopamine

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