Uptake inhibition of biogenic amines by newer antidepressant drugs: relevance to the dopamine hypothesis of depression
by
Randrup A, Braestrup C.
Psychopharmacology (Berl) 1977 Aug 16;53(3):309-14


ABSTRACT

The dopamine theory of depression was studied by assessing the effect of antidepressant drugs on uptake of dopamine, noradrenaline, and serotonin in synaptosomes from rat brain. Five newer drugs--butriptyline, maprotiline, trimipramine, iprindole, and mianserine--exhibited rather potent inhibition of 3H-dopamine uptake in corpus striatum, as their IC50 values, which were in the order of 10(-6)-10(-5) M, were only about 50 times higher than for nomifensine (IC50 = 10(-7) M). The five drugs were weak, compared to chlorimipramine, on 14C-serotonin uptake in the whole forebrain, as their IC50 were about 10(-5) M. Butriptyline, trimipramine, and iprindole were very weak uptake inhibitors of 3H-noradrenaline in the occipital cortex. Their IC50 values were about 10(-6) M, which is almost 1000 times higher than for desmethylimipramine. These results are discussed in relation to comprehensive recent literature as further indicating a link between dopamine and depression.
Nomifensine: profile
Nomifensine dependence
Imipramine versus nomifensine
Nomifensine : pharmacokinetics
Nomifensine and hemolytic anemia
Nomifensine, dopamine and yawning
Nomifensine, noradrenaline and dopamine



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