Effect of nomifensine on acetylcholine and
choline in the rat striatum and brainstem

by
Garattini S, Consolo S, Chitto G, Peri G, Ladinsky H.
Eur J Pharmacol 1976 Jan;35(1):199-201


ABSTRACT

Nomifensine, at a dose of 40 mg/kg, slightly but significantly increased rat striatal acetylcholine 60 min after i.p. administration without affecting choline levels or choline O-acetyltransferase and cholinesterase activities. This drug had no effect on brainstem acetylcholine. In contrast, d-amphetamine and desipramine both produced a small but significant increase in brainstem acetylcholine. It is suggested that nomifensine increased striatal acetylcholine indirectly through blockade of dopamine uptake.
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