Nomifensine and psychological
dependence - a case report
by
Yakabow AL, Hardiman S, Nash RJ
Pharmacopsychiatry 1986 Sep; 19(5):386-8

ABSTRACT

This case report indicates that nomifensine has not only a specific antidepressant profile but also a dose dependent addictive potential in patients with "addictive problems". Nomifensine supports not only norepinephrine transmission, but also acts on dopamine metabolism and this may be responsible for the stimulation of motor activity. This is in contrast to more frequently used tri- and tetracyclic antidepressants. This case report further supports other observations that several patients have psychological withdrawal difficulties after long term treatment with nomifensine in high doses (400-600 mg).

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Nomifensine, bupropion and cocaine

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