Characterization of the analgesic
properties of nomifensine in rats

by
Gilbert AK, Franklin KB.
Department of Psychology,
McGill University, Montreal, Quebec, Canada.
Pharmacol Biochem Behav 2001 Apr;68(4):783-787


ABSTRACT

The analgesic properties of the catecholamine uptake inhibitor nomifensine were investigated in the tail immersion, hot plate and formalin tests. Systemic administration of nomifensine produced analgesia only in the formalin test. The analgesia was dose-dependent (0.625-5 mg/kg), and the highest dose completely abolished nociceptive behaviors induced by 2% formalin. The analgesia was not affected by the opioid antagonist naltrexone (2.5-40 microg s.c.) but was dose-dependently reversed by the D2 antagonist eticlopride (181.3-270 microg/kg i.p.). Neither naltrexone nor eticlopride affected formalin pain scores. Nomifensine analgesia appears to be dopamine-mediated but independent of opioid mechanisms.
Dopamine
Bupropion
Naltrexone
Amineptine
Noradrenaline
Methylphenidate
Nomifensine: an overview
Nomifensine: pharmacology
Nomifensine and methylphenidate
Nomifensine and hemolytic anemia
Nomifensine, bupropion and cocaine



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